trisomy 21

'trisomy 21' receives 135,000 monthly searches globally. That's strong demand without overwhelming competition, which is an attractive combination for sellers. Most of this demand (100%) comes from Others.

There are 2,527 Etsy listings competing for 'trisomy 21'. Relative to the search demand, that's low saturation. Well-optimized listings can rank on the first page without needing an extensive sales history — this is the kind of keyword where newer shops can gain a foothold. Most competition comes from United States sellers (68%), while demand is strongest in Others — a gap worth exploiting.

'trisomy 21' has a keyword difficulty of 12/100 (easy). The low difficulty makes it accessible for shops of all sizes. Even without extensive reviews, you can rank well with a properly optimized listing.

Others generates 100% of searches for 'trisomy 21'. Competition is centered in United States instead, which means Others buyers have fewer options tailored to them — an opening for sellers who can cater to that market.

Since 'trisomy 21' is a broad, short keyword, Etsy will match it against thousands of listings. Your title needs to lead with this keyword followed by descriptive modifiers that signal exactly what you sell. Given the low difficulty, a complete listing with good photos and all 13 tags filled should be enough to reach the first page. Focus on getting your first few sales and reviews to lock in your position.

The cost per click for 'trisomy 21' is $0.47. Low advertiser activity combined with low organic competition suggests this keyword may be overlooked by larger sellers. That's often where the best opportunities are — less noise, more targeted buyers.

Search volume rose 49% between October 2025 and September 2026. A 49% increase on an already high-volume keyword signals growing opportunity — but expect more sellers to notice. Getting established now gives you a head start before competition catches up. Search interest was highest around September 2026.